Excess body weight is implicated as a risk factor for many different disorders, including heart disease, diabetes, several other conditions. The key to losing weight is wanting to do it badly enough and finding the motivation to carry it through. To start with, you need to ask yourself who you are losing weight for. If the answer is ‘me’ you’ll find it easier. These drugs help you lose weight by acting on the appetite control centers in the brain, creating a sense of fullness, causing the patient to feel physically satisfied with less food than usual.